KMID : 1146220230310030125
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Journal of Cardiovascular Imaging 2023 Volume.31 No. 3 p.125 ~ p.132
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Cardiac Phenotyping of SARS-CoV-2 in British Columbia: A Prospective Echo Study With Strain Imaging
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Jeffrey Yim
Michael Y.C. Tsang Anand Venkataraman Shane Balthazaar BScKin Ken Gin John Jue Parvathy Nair Kim Tae-Young Darwin F. Yeung Robb Moss Sean A Virani Jane McKay Margot Williams Eric C. Sayre Purang Abolmaesumi Teresa S.M. Tsang
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Abstract
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BACKGROUND : There is limited data on the residual echocardiographic findings including strain analysis among post-coronavirus disease (COVID) patients. The aim of our study is to prospectively phenotype post-COVID patients.
METHODS : All patients discharged following acute COVID infection were systematically followed in the post-COVID-19 Recovery Clinic at Vancouver General Hospital and St. Paul¡¯s Hospital. At 4?18 weeks post diagnosis, patients underwent comprehensive echocardiographic assessment. Left ventricular ejection fraction (LVEF) was assessed by 3D, 2D Biplane Simpson¡¯s, or visual estimate. LV global longitudinal strain (GLS) was measured using a vendor-independent 2D speckle-tracking software (TomTec).
RESULTS : A total of 127 patients (53% female, mean age 58 years) were included in our analyses. At baseline, cardiac conditions were present in 58% of the patients (15% coronary artery disease, 4% heart failure, 44% hypertension, 10% atrial fibrillation) while the remainder were free of cardiac conditions. COVID-19 serious complications were present in 79% of the patients (76% pneumonia, 37% intensive care unit admission, 21% intubation, 1% myocarditis). Normal LVEF was seen in 96% of the cohort and 97% had normal right ventricular systolic function. A high proportion (53%) had abnormal LV GLS defined as < 18%. Average LV GLS of septal and inferior segments were lower compared to that of other segments. Among patients without pre-existing cardiac conditions, LVEF was abnormal in only 1.9%, but LV GLS was abnormal in 46% of the patients.
CONCLUSIONS : Most post-COVID patients had normal LVEF at 4?18 weeks post diagnosis, but over half had abnormal LV GLS.
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KEYWORD
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COVID-19, SARS-CoV-2, Echocardiography, Strain imaging, Speckle tracking echocardiography
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